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For women who received estrogen alone, the findings were less certain. HRT in this group was associated with an increased risk for stroke and venous thrombosis, and a lowered risk for hip and total fractures. After discontinuation of therapy most of the effects were no longer evident. The investigators were surprised by and at a loss to explain a small nonsignificant drop in breast cancer. Following discontinuation of HRT this decrease achieved statistical significance. Women under the age of 60 in this group also had small but signifcant reductions in all-cause mortality and myocardial infarction.
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